vmware The vSphere Command-Line Interface (vSphere CLI) command set allows you to run common system administration commands against ESX/ESXi systems from any machine with network access to those systems. You can also run most vSphere CLI commands against a vCenter Server system and target any ESX/ESXi system that vCenter Server system manages. vSphere CLI commands are especially useful for ESXi hosts because ESXi does not include a service console.